Where you place  your Google Adsense is very important in how successful you will be getting the most out of your ads!

Viewing the Google "Heat Map" will help you in your placement. Some sites don't have this capability to maximize it,  but if you can use a few of the key areas, you should see some positive results.

The colors fade from dark orange (strongest performance) to light yellow (weakest performance). All other things being equal, ads located above the fold tend to perform better than those below the fold. Ads
placed near rich content and navigational aids usually do well because
users are focused on those areas of a page.

While this heat map is useful as a positioning guideline, we strongly recommend putting your users first when deciding on ad location. Think about their behavior on different pages, and what will be most useful
and visible to them. You'll find that the most optimal ad position isn't
always what you expect on certain pages.

For example, on pages where users are typically focused on reading an article, ads placed directly below the end of the editorial content tend
to perform very well. It's almost as if users finish reading and ask
themselves, "What can I do next?" Precisely targeted ads can answer that
question for them.

reference- Google.com

One thing to note too is that since every site is unique, you may have to play with the placement to fully optimize it. For example, the  content of your site as well as the color of the titles or text for your ads may also change the frequency of clicks. Many factors affect the success of your ads and it may take you some time to get the most out of it!